𝛃-lactam antibiotics Beta lactam ring 𝛃-lactam antibiotics are the class of drugs having a 𝛃-lactam group in the molecular structure of the compound. There are mainly two sub groups in the 𝛃-lactam antibotics 1) Penicillins 2) Cephallospoins Other groups are monobactam and carbapenems (relatively newer addition) The main mechanism of action of 𝛃-lactam antibiotics is through inhibition of transpeptidase enzyme, hence inhibition of cell wall formation. Penicillins: Penicillins are the first antibiotics to be used clinically as antibiotics. Penicillins were first obtained from Penicillium Notatum , and present source is through Penicillium Chrysogenum . Chemistry: Penicillins have two rings perfused together namely one is the 𝛃-lactum ring and the other one is the thiazolidine ring, an side chain is attached through the 𝛃-lactam ring through an amide linkage. The first used Penicillin was Penicillin G, structurall...
this page deals with the beta lactam antibiotics and their mechanism of resistance and mechanism of action
Comments
Post a Comment