Pharma Preparation

𝛃-lactam antibiotics Beta lactam ring 𝛃-lactam antibiotics are the class of drugs having a 𝛃-lactam group in the molecular structure of the compound. There are mainly two sub groups in the 𝛃-lactam antibotics 1)  Penicillins 2)  Cephallospoins Other groups are monobactam and carbapenems (relatively newer addition) The main mechanism of action of 𝛃-lactam antibiotics is through inhibition of transpeptidase enzyme, hence inhibition of cell wall formation. Penicillins: Penicillins are the first antibiotics to be used clinically as antibiotics. Penicillins were first obtained from Penicillium Notatum , and present source is through Penicillium Chrysogenum . Chemistry: Penicillins have two rings perfused together namely one is the 𝛃-lactum ring and the other one is the thiazolidine ring, an side chain is attached through the 𝛃-lactam ring through an amide linkage. The first used Penicillin was Penicillin G, structurall...